Fatty acid vinyl esters were synthesised from the corresponding free fatty acids in 79%-84% yield using Hg (OAc)₂/H₂SO₄ under microwave irradiation. Subsequently, the obtained fatty acid vinyl esters were utilised for the lipase catalysed acylation of vitamin C under microwave heating. Various lipases viz. Pseudomonas cepacia, Porcine pancreatic, Candida rugosa, Mucor miehei, Rhizopus oryzae and Novozyme-435 were screened for the acylation of vitamin C under microwave irradiation. Among these lipases, Novozyme-435 was found to be the best catalyst for this reaction. Five different ascorbyl esters were synthesised in 58%-85% yield in 3 hr using Novozyme-435.