Journal of Oil Palm Research Vol. 25  2013 August p.  208-215
DOI:

Differential and antagonistic effects of palm tocotrienols and other phytonutrients (carotenoids, squalene and coenzyme Q10) on breast cancer cells in vitro

Author(s): RADHIKA Loganathan * ; KANGA RANI Selvaduray * ; KALANITHI Nesaretnam * ; AMMU KUTTY Radhakrisnan**

Palm vitamin E, tocotrienols in particular, are known to exert great anti-cancer effects on a variety of cell types. In this study, the effects of palm vitamin E, carotenoids, squalene and coenzyme Q10 were studied on two human breast cancer cell lines. All compounds caused anti-proliferative effect in vitro but tocotrienols (compounds and isomers) were generally more potent. The results show that the anticancer effects of palm vitamin E were more pronounced when these were used on their own rather than in combination with other phytonutrients (carotenoids, squalene and coenzyme Q10). The palm phytonutrient complex, which contains all the tested phytonutrients did not appear to exert better antiproliferative effects compared to the individual compounds. Our results show that tocotrienols, as well as other phytonutrients (carotenoids, squalene and coenzyme Q10), have anti-proliferative effects on breast cancer cells but different and antagonistic mechanisms may be employed in combination.

Keywords: , , , ,

Author Information
* Malaysian Palm Oil Board, 6 Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia.

** Pathology Division, Faculty of Medicine, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.
E-mail: ammu_radhakrishnan@imu.edu.my


Cited By

(26)
1) De Los Reyes, M., Oyong, G., Ng, V.S., Shen, C.-C., Ragasa, C. Cytotoxic Compounds from Wrightia pubescens (R.Br.) (2018) Pharmacognosy Research, 10 (1), pp. 9-15.
2) Macuha, M.R., Shen, C.-C., Ragasa, C.Y. Chemical constituents of Kosteletzkya batacensis (Blanco) Fern.-Vill. (2017) Asian Journal of Chemistry, 29 (9), pp. 1969-1971.
3) De Los Reyes, M.M., Oyong, G.G., Ng, V.A.S., Shen, C.-C., Ragasa, C.Y. Cytotoxic compounds from kibatalia gitingensis (Elm.) woodson (2017) Pharmacognosy Journal, 9 (1), pp. 8-13.
4) De Los Reyes, M.M., Oyong, G.G., Ng, V.A.S., Shen, C.-C., Ragasa, C.Y. Cytotoxic compounds from Dysoxylum gaudichaudianum (A. Juss.) Miq. (2016) International Journal of Pharmacognosy and Phytochemical Research, 8 (4), pp. 663-667.
5) Apostol, P.G., De Los Reyes, M.M., Mandia, E.H., Shen, C.-C., Ragasa, C.Y. Chemical constituents of Ficus minahassae (Teijsm. & de Vriese) Miq (2016) Der Pharma Chemica, 8 (20), pp. 220-223.
6) Drotleff, A.M., Büsing, A., Willenberg, I., Empl, M.T., Steinberg, P., Ternes, W. HPLC Separation of Vitamin E and Its Oxidation Products and Effects of Oxidized Tocotrienols on the Viability of MCF-7 Breast Cancer Cells in Vitro (2015) Journal of Agricultural and Food Chemistry, 63 (40), pp. 8930-8939.
7) Biona, K., Shen, C.-C., Ragasa, C.Y. Chemical constituents of Talinum triangulare (2015) Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6 (1), pp. 167-171.
8) Ragasa, C.Y., Ebajo, V.D., Jr., De Los Reyes, M.M., Brkljaca, R., Urban, S. Chemical constituents of Polyscias nodosa (2015) Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6 (5), pp. 1210-1214.
9) Ragasa, C.Y., Ebajo, V., Jr., De Los Reyes, M.M., Mandia, E.H., Brkljača, R., Urban, S. Triterpenes from Calophyllum inophyllum linn (2015) International Journal of Pharmacognosy and Phytochemical Research, 7 (4), pp. 718-722.
10) Ragasa, C.Y., Ebajo, V.D., Jr., de Los Reyes, M.M., Shen, C.-C. Terpenoids from Eucalyptus deglupta (2015) Der Pharma Chemica, 7 (1), pp. 224-229.
11) Ragasa, C.Y., Caro, J.L., Shen, C.-C. Chemical constituents of Artocarpus ovatus Blanco (2015) Der Pharma Chemica, 7 (2), pp. 178-182.
12) Ragasa, C.Y., Ebajo, V.D., Jr., Lazaro-Llanos, N., Brkljača, R., Urban, S. Chemical constituents of Hypnea nidulans setchell (2015) Der Pharma Chemica, 7 (10), pp. 473-478.
13) Ebajo, V.D., Jr., Shen, C.-C., Ragasa, C.Y. Terpenoids and sterols from Hoya multiflora Blume (2015) Journal of Applied Pharmaceutical Science, 5 (4), pp. 33-39.
14) Ragasa, C.Y., Ng, V.A.S., Ulep, R.A., Brkljača, R., Urban, S. Chemical constituents of Champereia manillana (Blume) Merrill (2015) Der Pharmacia Lettre, 7 (7), pp. 256-261.
15) Ng, V.A.S., Agoo, E.M.G., Shen, C.-C., Ragasa, C.Y. Chemical constituents of Cycas sancti-lasallei (2015) Journal of Applied Pharmaceutical Science, 5, pp. 12-17.
16) Ragasa, C.Y., Ebajo, V.D., Jr., De Los Reyes, M.M., Mandia, E.H., Brkljača, R., Urban, S. Triterpenes and sterols from Sonneratia alba (2015) International Journal of Current Pharmaceutical Review and Research, 6 (6), pp. 256-261.
17) Ragasa, C.Y., Tan, M.C.S., Chiong, I.D., Shen, C.-C. Chemical constituents of Muntingia calabura L. (2015) Der Pharma Chemica, 7 (5), pp. 136-141.
18) De Los Reyes, M.M., Oyong, G.G., Ebajo, V.D., Jr., Ng, V.A.S., Shen, C.-C., Ragasa, C.Y. Cytotoxic triterpenes and sterols from Pipturus arborescens (link) C.B. Rob. (2015) Journal of Applied Pharmaceutical Science, 5 (11), pp. 23-30.
19) Ragasa, C.Y., Torres, O.B., Mandia, E.H., Shen, C.-C. Chemical constituents of Terminalia microcarpa Decne (2014) Der Pharmacia Lettre, 6 (6), pp. 439-442.
20) Ragasa, C.Y., Ng, V.A.S., de Los Reyes, M.M., Mandia, E.H., Shen, C.-C. Triterpenes and a coumarin derivative from Kibatalia gitingensis (Elm.) Woodson (2014) Der Pharma Chemica, 6 (5), pp. 360-364.
21) Ragasa, C.Y., Ng, V.A.S., De Los Reyes, M.M., Mandia, E.H., Oyong, G.G., Shen, C.-C. Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq. (2014) Der Pharma Chemica, 6 (5), pp. 182-187.
22) Ragasa, C.Y., Buluran, A.I., Mandia, E.H., Shen, C.-C. Chemical constituents of Cayratia trifolia (2014) Der Pharma Chemica, 6 (6), pp. 418-422.
23) Ragasa, C.Y., Ng, V.A.S., de Los Reyes, M.M., Mandia, E.H., Shen, C.-C. Chemical constituents of Wrightia pubescens (R.Br.) (2014) Der Pharmacia Lettre, 6 (6), pp. 14-19.
24) Ragasa, C.Y., Ng, V.A.S., Ebajo, V.D., Jr., Fortin, D.R., de Los Reyes, M.M., Shen, C.-C. Triterpenes from Shorea negrosensis (2014) Der Pharmacia Lettre, 6 (6), pp. 453-458.
25) Ragasa, C.Y., Ebajo, V.D., Jr., Ng, V.A.S., De Los Reyes, M.M., Shen, C.-C. Chemical constituents of Strongylodon macrobotrys (2014) Der Pharma Chemica, 6 (6), pp. 366-373.
26) Ragasa, C.Y., Ng, V.A.S., Ebajo, V.D., Jr., de Los Reyes, M.M., Mandia, E.H., Shen, C.-C. Chemical constituents of Pipturus arborescens (Link) C.B. Rob (2014) Der Pharmacia Lettre, 6 (6), pp. 35-42.

Source: Scopus
Last updated: 30 July 2018

Call For Papers

Article In Press

Search for:


Most cited articles


SIGN UP To JOPR MAILING LIST

Subscribe with us to get the latest information on Palm Oil Research from MPOB today!