In Malaysia, the tocotrienols-rich fraction (TRF) is used as one of the functional ingredients in cosmetics products. The tropically applied vitamin E plays a role in protecting the skin from free radicals damage induced by the ultraviolet radiation. The formulation of new tropical products always includes risk of unexpected cutaneous side efects in certain individuals. Although the irritant contact dermatitis (ICD) has been reported for many compounds including active substances in cosmetics, the local topical ICD of TRF preparations has not been reported. This article decribes the safety evalutions of palm TRF on skin. The primary irritation potential was assessed through animal study while the ICD was determined using patch testing technique on healthy as well as highly sensitive patients. The sensitization potential was evaluated using human repeated insult patch test on helathy subjects. Results indicated that the palm TRF din dont induced any cutaneous irritation or sensitization at 1%, 2.5% and 5%.