The Malaysian Palm Oil Board’s (MPOB) oil palm genetic materials were evaluated for Ganoderma infection in Ganoderma hotspots at the MPOB Research Station in Bagan Datuk, Perak, Malaysia. The objectives of the study were to investigate the development of the disease among oil palm genetic materials [dura x dura (DxD), dura x pisifera (DxP) and D-selfed] and subsequently to identify progenies having partial resistance to the basal stem rot (BSR) disease caused by Ganoderma. The progenies were planted in 2008 in a completely randomised design in an area formerly cultivated with oil palm but devastated by Ganoderma, hence regarded as a Ganoderma hotspot. Field census for symptoms of palms with Ganoderma infection was conducted for eight years, four years after field planting. The study showed a low infection rate of less than 10%, hence potential partial resistance on 31 (10 DxD, 13 DxP and eight D-selfed) progenies. The partial resistance of the 31 progenies will need to undergo further reconfirmation via screening in the nursery using established techniques prior to being utilised for the production of partial resistance planting materials. Upon confirmation of the partial resistance, utilising parents linked to the DxD, D-selfed and DxP progenies could undergo further breeding and improvement before being utilised as maternal parents for seed production. Individual palms from the DxP progenies could also be directly mass propagated via cloning for immediate utilisation.