Journal of Oil Palm Research Vol.   p.  
DOI: https://doi.org/10.21894/jopr.2020.0082

PALM TOCOTRIENOLS CAUSE CLEAVAGE OF POLY-(ADP)-RIBOSE POLYMERASE ENZYME AND DOWN-REGULATION OF CYCLOOXYGENASE-2 PROTEIN LEVEL IN HUMAN BREAST CANCER CELLS

Author(s): RADHIKA LOGANATHAN*; KANGA RANI SELVADURAY*; KALANITHI NESARETNAM*; AMMU KUTTY RADHAKRISHNAN**,‡

Breast cancer is a leading cause of cancer-related deaths in women globally. The anti-cancer effects of various forms of vitamin E from palm oil [tocotrienol-rich fraction (TRF): natural form of vitamin E complex in palm oil, tocotrienol-enriched fraction (TEF), and major vitamin E homologues in palm oil: a-tocopherol (aToc) and tocotrienols (T3) (a, d or g)] were tested on two human breast cancer cell lines [MDA-MB-231 (triple negative) and MCF-7 (oestrogen-dependent)]. Chronic inflammation plays a key role in tumourigenesis. Both cell lines used express high levels of poly-(ADP)-ribose polymerase (PARP-1) and cyclooxygenase-2 (COX- 2), which are key mediators of inflammation. Tocotrienols exerted marked anti-proliferative by promoting apoptosis in both MDA-MB-231 and MCF-7 cells. In addition, T3 also induced time-dependent inactivation of PARP-1 as well as inhibited expression of COX-2 in both MDA-MB-231 and MCF-7 cells. The rate of T3 uptake was found to be comparable to the anti-proliferative and apoptotic activities observed. In conclusion, T3 induced marked anti-proliferative (p<0.05) and pro-apoptotic (p<0.05) effects, which were most l

Keywords: , , , , , ,

Author Information
* Malaysian Palm Oil Board, 6 Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia.

** School of Medicine, Faculty of Medicine and Health, International Medical University, Bukit Jalil, 55100 Kuala Lumpur, Malaysia

‡ Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 47500 Bandar Sunway, Selangor, Malaysia.
E-mail: ammu.radhakrishnan@monash.edu


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