Bud rot (BR) is a disease caused by the oomycete Phytophthora palmivora, which affects oil palm plantations in Latin America. It is one of the most limiting factors in oil palm cultivation in the region. In order to evaluate the agronomic response of commercial cultivars of oil palm in Colombia, six Malaysian cultivars (M1 to M6) and three regional cultivars (R1 to R3) were planted in 2004 under two contrasting agronomic conditions in two locations (Barranca de Upía and Acacías) located in the Eastern Plains of Colombia, where there is disease remission of the palms. One of the parameters evaluated was the reaction of cultivars to BR. The response variables were the area under the disease progress curve (AUDPC) and time to disease remission (RT) in months. There were significant differences in AUDPC and RT among the cultivars planted at Barranca de Upía. However, at Acacias there were no significant differences among the cultivars. M5 and M6 were the Malaysian cultivars with lower incidence of BR at Barranca de Upía. At the same time, M6 was the material with the least time to remission.